The last three videos I have made, I have had to take down. I hurried up and made a video with some new information i ran across. Nitric oxide. I kept getting the role of this chemical mixed up in my mind.. As my understanding increased, I saw just how much I had the idea of nitric oxides’ role turned around. The hypercoagulation due to fibrin I have understood for quite awhile. The role of my sleep apnea in the severity of my MS I have understood for awhile. (intervention for my sleep apnea greatly reduced exacerbation The nitric oxide I misunderstood TERRIBLY. It took a peer-reviewed NEUROLOGY article to help me understand. Nitric oxide is GOOD and BAD. Unfortunately with MS, I believe it is what does the most damage. Here is a link to the article that made it clear to me what the role of nitric oxide is: lansbury.bwh.harvard.edu God bless Harvard, yo! Anyway, if it takes a big man to admit he is wrong…………………………….. then my name is Atlas. 
God bless, Mark
Dottor T. Il divulgatore scientifico
@pgfracing
I am overweight but I have been working on it.
I have lost 50 lbs since spring. Since my Liberation from CCSVI, my body is now making it to where I can exercise.
I was BIG before, but multiple sclerosis made me “fat” because I would get intense vertigo every time I tried to exercise.
We all love you too! You’re not an idiot bro.. how you just explained all that made good sense.. I always learn something new from your videos..
thanx
Omario
p.s. the angle on you camera with a different background kind of confused me
Thank you for your humility, time, effort and research! Don’t be so hard on yourself.
I hate to mention this, but…I hate for you to take the other 3 videos off because they had such amazing info. in them. It would be great for you to re-do the rest of what you said in the other videos. Your message is amazing and needs to be out there!
I read Nitric Oxide is bad for deep vein thrombosis about 5 years ago, so it made sense to me it was also bad for MS / CCSVI.
You are so type A. Knock it off! You are fabulous!
Mark you look great and you NEVER look like an idiot.
I’m going to re watch this after i get some sleep. I am a total fuzzy head right now. this is important stuff. You are trying very hard to help people. No harm in correcting things. its like having a discussion and you are having an open talk. I’ll rewatch this if I can lose some brain fog. Huggles, Jude
Comment Part 1: Hi Mark and thanks for this video! The science is a bit hard to follow, but if I understand you correctly, your theory is that high Nitric Oxide levels triggered by CCSVI are the main cause of myelin and axon damage in MS (not necessarily the immune system). This sounds quite plausible, especially given that exacerbations often follow periods of high stress. Recently I went for a CCSVI screening in Glasgow(EHC) where they also took a Nitrotyrosine blood test for research purposes
Comment Part 2: I understand Nitrotyrosine to be related to Nitric Oxide. EHC in their literature states: “nitrotyrosine …is a biomarker for peroxynitrite activity. Peroxynitrites are thought to be the molecules which damage the cell membranes of the myelin sheath and nerve cells”. I scored at a 225 level (where <20 is normal). I was told that a score in the 1000-level was not uncommon in MS. It sounds like you hit this nail on the head! Now I need to find out what the score means. Best, Ann
@irishbear76 Good job 50lbs is quite the accomplishment. I walk for exercise however I need to bump it up to where I’m breathing a little harder to get my lungs and heart into it also. Glad to read you are doing a better.
@pgfracing
Thanks. Good luck and God bless.
LOL. Your videos keep disappearing from my favourites Mark. Don’t worry about updating them. This is one of the hallmarks of good science. The only way it can progress is by improving & changing existing theories.
I am getting thoughts of that old saying, what came first? The chicken or the egg? What caused all the troubles of our MS first? Nitric Oxide or Fibrin? If Fibrin is stopping the flow of blood from our Jugular veins then it is no wonder that Nitric Oxide levels increase because it is building up in there!! Not 100% trapepd but fairly close. Our arteries supply Nitric Oxide. So it is looking like that Nitric Oxide the thing that is really causing our demyelination.
Irish Bear that was a great explanation, thank you. I have MS and sleep apnea (won’t live without my CPAP). You really made it understandable. Thank you.
You are always so very interesting! Thank you so much
Mark, I love learning alongside with you. I have never felt misguided by you – your knowledge and articulation are far far better and more than I have ever heard from anyone else in the med field – please do not hesitate to state your knowledge as it comes, it is like taking a trip **with** your brain
It is all Love that directs the Wisdom. It all makes sense. And NO – there is absolutely NO cognitive dysfunction going on in your words!!!!!!!!!!!!!!!!!!!!!!!!
@anncarolg1
That is exactly what I am saying (and thinking even more).
If you look at the link in the description, I took a Neurology article that implicates nitric oxide in the CSF and brain for white matter/ axonal damage.
@Gtlr123
I actually think I am correct.
Despite really having it wrong early on.
I feel that I am right on.
CCSVI led me to this point.
Once we start changing our preconceptions about what we THINK MS is, we will KNOW what it is.
This is the first step to curing it.
@mandi7and10
This has been a growing experience for me.
It is always good for me to feel “stupid” from time to time.
It just reminds me I have so much more to learn.
I am on it with this video.
I am directly on it.
Please read the Neurology article in the description.
@CTYankeeMS
Between the CPAP and my Liberation Procedure.
I am enjoying my 2 month anniversary since I last felt ANY MS symptom.
Praise be to God.
@notapplicable66
SInce the nitric oxide flood occurs after the hypercoagulation….
This is how I see it.
CCSVI causes blood to reflux and begin the coagulation cascade.
Receptors in vessel walls trigger the body to produce N.O. to thin the blood and dilate veins.
THe N.O. stops the blood from clotting, but the brain is flooded with the stuff.
The N.O. begins to damage white matter and axons of neurons .
Cause CCSVI
Effect N.O. production
After effect- progressive disabillity (damage)
@rickileeway
There was some great stuff on my other vids but I had to remove them due to a couple of things that concerned me about them..
@anncarolg1
Go ahead and put your index finger on your nose.
This is also what I am finding.
I believe 10/12/10 was an important day for me.
That is when true understanding of this happened.
It was a eureka moment to sayt he least.
Please tell Scottish doctors about this!!!
so if hypotetically i were to take nitric oxide supplements, i’d probably have another remmitent MS episode huh?
Hey Mark – sent you PM earlier today. I will continue to research and fight for the ccsvi discovery procedure to become part of “normal protocol” even though after the venogram today no blockage was found. Vascular surgeon is very interested and curious. I’m wondering now if it has something to do with the length of time of diagnosis and maybe even past usage of DMD’s. Since diagnosis and first symptoms have only been in last 5 months and no DMD’s have been taken besides 2 steroid treatments. T
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